Image Glossary > Stem Cells

There are many different types of stem cells within our body.  Each type of stem cell is defined by the group of specialized cells it gives rise to.  However, there are two fundamental properties that distinguish all stem cells, including induced pluripotent stem cells, from other somatic cells: self-renewal and potency.

Self-renewal describes the process where a stem cell undergoes mitotic cell division that yields at least one daughter cell with equivalent developmental potential as the mother cell - i.e. another stem cell.  The capacity to self-renew varies based on the type and age of the stem cells.  Induced pluripotent stem cells and embryonic stem cells maintain the ability to self-renew indefinitely under proper culture conditions.  Multipotent stem cells, such as hematopoietic stem cells, have more limited capacity for self-renewal.  Self-renewal is a necessary cellular function to maintain a sufficient number of stem cells within different tissues and organs of the body for the maintenance/repair of lost or damaged cells/tissue. 

The second distinguishing property of a stem cell is the ability to differentiate into mature specialized cell types.  The number of specialized cell types a stem cell can produce determines its potency (e.g. totipotent, pluripotent, multipotent, unipotent). Stem cells that give rise to all cell types of the body, including the embryonic components of the trophoblast and placenta, are totipotent stem cells.  These stem cells are derived from the pre-implantation embryo at the morula stage of embryonic development.

Induced Pluripotent Stem Cell A somatic cell that has been reprogrammed to exhibit pluripotent stem cell properties. Many somatic cells have been... Read More

iPS Colony Refers to the tightly packed homogenous cluster of induced pluripotent cells. Undifferentiated embryonic stem cells and... Read More

Fibroblast A type of cell in loose connective tissue that secretes the protein ingredients of the extracellular matrix. Many somatic cells have been ... Read More

Reprogramming Factors In 2006, the Yamanaka lab identified four factors that, when co-transfected and expressed in mouse adult fibroblast cells, caused.... Read More

Chromatin The complex of DNA and DNA-binding protein that makes up a eukaryotic chromosome. The DNA is wrapped around histone proteins... Read More

Retrovirus An RNA virus that fuses to surface receptors located within the host cell's plasma membrane. After binding, the membrane of the... Read More

Reverse Transcriptase A DNA polymerase enzyme that transcribes single-stranded RNA into double-stranded DNA which is then integrated into the host ... Read More

Transcription Factor A regulatory protein that binds to DNA and affects the transcription of specific genes. The four reprogramming factors, Oct-4, SOX2, Klf-4... Read More

Cellular Reprogramming Cellular reprogramming describes the process where a fully differentiated, specialized cell type is induced to transform into a different... Read More